Citation
Ek. Seo et al., New biphenyl compounds with DNA strand-scission activity from Clusia paralicola, J NAT PROD, 62(11), 1999, pp. 1484-1487
Citations number
25
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864
→ ACNP
Volume
62
Issue
11
Year of publication
1999
Pages
1484 - 1487
Database
ISI
SICI code
0163-3864(199911)62:11<1484:NBCWDS>2.0.ZU;2-P
Abstract
Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3),
were isolated from the roots of Clusia paralicola by bioassay-directed fra
ctionation using the DNA strand-scission and the KB human cancer cell line
cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA s
trand-scission assay, whereas all three compounds exhibited modest cytotoxi
city against the KB cell line. The structures of 1-3 were elucidated by spe
ctroscopic methods including 1D and 2D NMR techniques.