Af. Barrero et al., Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol, J NAT PROD, 62(11), 1999, pp. 1488-1491
The first syntheses are reported for recently isolated drimanes 11,12-epoxy
drim-8,12-en-11-ol (2) and 11,12-diacetoxydrimane (3), from (-)-sclareol (1
). Furthermore, two efficient new routes to the potent bioactive warburgana
l (4) starting also from 1 are described.