Cytotoxic terpenoids from the formosan soft coral Nephthea brassica

Authors
Duh, CY Wang, SK Weng, YL Chiang, MY Bai, CF
Citation
Cy. Duh et al., Cytotoxic terpenoids from the formosan soft coral Nephthea brassica, J NAT PROD, 62(11), 1999, pp. 1518-1521
Citations number
12
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
11
Year of publication
1999
Pages
1518 - 1521
Database
ISI
SICI code
0163-3864(199911)62:11<1518:CTFTFS>2.0.ZU;2-2
Abstract
Two new cytotoxic cembranoid diterpenes, brassicolide (1) and brassicolide acetate (2); a new cytotoxic sesquiterpene, (-)-4 alpha-O-acetyl-selin-11-e n (3); and six cytotoxic terpenoids, (-)-selin-11-en-4 alpha-ol (4), 2-hydr oxynephthenol (5), nephthenol (6), cembrene A (7), epoxycembrene A (8), and (-)-beta-elemene (9), have been isolated from the Formosan soft coral Neph thea brassica. The structures of compounds 1-9 were determined by spectral, chemical, and X-ray crystallographic analysis.