Cl. Barr et al., Synthesis and characterization of verdazyl radicals bearing pyridine or pyrimidine substituents: A new family of chelating spin-bearing ligands, J ORG CHEM, 64(24), 1999, pp. 8893-8897
The syntheses and characterization of two new 1,5-dimethyl-6-oxoverdazyl ra
dicals bearing a-pyridine and 4,6-dimethyl-2-pyrimidine rings as substituen
ts are described. The radical precursors, the corresponding 1,2,4, 5-tetraz
anes, were prepared by condensation of the bis(1-methylhydrazide) of carbon
ic acid with the appropriate aromatic aldehyde. Oxidation of 3-(4,6-dimethy
l-2-pyrimidyl)1,5-dimethyl-1,2,4,5-tetrazane 6-oxide (7) with sodium period
ate afforded 1,5-dimethyl-3-(4,6-dimethyl-2-pyrimidyl)-6-oxoverdazyl (4), w
hich could be isolated and stored without decomposition. In contrast, attem
pts to oxidize the analogous 3-(2-pyridyl)-1,5-dimethyl-1,2,4,5-tetrazane 6
-oxide (6) with periodate produced the 1,5-dimethyl-3-(2-pyridyl)-6-oxoverd
azyl (3) which could not be isolated. However, oxidation of this tetrazane
with benzoquinone produced the pyridylverdazyl 3 as a 1:1 complex with hydr
oquinone. This complex is indefinitely stable in the solid state and provid
es;a means of long-term storage of the pyridylverdazyl. The electronic prop
erties of both radicals have been characterized by EPR spectroscopy, cyclic
voltammetry, and MNDO calculations. The radicals have a wide electrochemic
al window of stability (>1.8 V), and the EPR and computational studies indi
cate a large spin density residing on N2 and N4.