To determine whether the bacterial toxins associated with otitis media coul
d induce morphologic changes in the organ of Corti, we inoculated the middl
e-ear cavities of healthy guinea pigs with either Streptococcus pneumoniae
or sterile saline and then examined the organ of Corti histologically at 1,
2, and 3 weeks postinoculation. We found that the outer hair cells (OHCs)
in the infected ears underwent several changes that were dependent on both
the length of time following inoculation and also the position of the OHCs
in the cochlea. At 2 weeks postinoculation, 7.0 to 20% of the OHC nuclei fr
om the infected animals became very swollen, with the most significant swel
ling occurring in the basal turn. At 3 weeks postinoculation, 2.5 to 3.5% o
f the OHCs were missing in the infected animals, with the most significant
loss occurring in the basal and middle turns. These results suggest that ba
cterial otitis media can produce cytotoxic changes in the cochlea. These ch
anges may be a clinically significant factor in the temporary and permanent
sensorineural hearing loss that has been associated with bacterial otitis
media.