M. Heckmann et al., Side-controlled intradermal injection of botulinum toxin A in recalcitrantaxillary hyperhidrosis, J AM ACAD D, 41(6), 1999, pp. 987-990
Background: Although topical application of aluminium chloride is the most
common measure against axillary sweating, severely affected patients often
undergo surgical procedures that are expensive and may have considerable si
de effects. Recently botulinum toxin A (BT-A) has been reported as a potent
ially effective antihyperhidrotic agent.
Objective: Our purpose was to determine the therapeutic strength, safety, a
nd mode of application of BT-A in severe axillary hyperhidrosis.
Methods: Intradermal injection of BT-A (Dysport) was given in an open left-
versus-right side trial with each patient being his own control for initial
efficacy, followed by treatment of the contralateral side.
Results: Seven days after initial treatment sweat production fell to below
10% of the untreated contralateral axilla as determined by gravimetry. Sati
sfaction was rated unanimously as "very good," the highest of 5 rankings. N
o side effects such as skin irritation or muscle weakness were noted in any
patient.
Conclussion: Intradermal injection of BT-A isa potent and well-accepted the
rapeutic option in patients with recalcitrant axillary hyperhidrosis.