Grover's disease in patients with chronic renal failure receiving hemodialysis: Clinicopathologic review of 4 cases

In 4 patients undergoing hemodialysis for chronic renal failure, a transien t or persistent, papular and keratotic eruption developed on the trunk and arms. Histologic examination disclosed focal acantholysis with dyskeratosis . The lesions were clinically and histologically indistinguishable from tho se of Grover's disease. A possible association with Grover's disease and ch ronic renal failure and/or hemodialysis is postulated Possible implicated p athogenic mechanisms are discussed. We suggest that Grover's disease should be included in the differential diagnosis of cutaneous eruptions in patien ts with chronic renal failure.