New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole

As part of a research program aiming at the synthesis and pharmacological e valuation of novel lead-compounds exploring Brazilian abundant natural prod ucts, we describe herein the synthesis and the antithrombotic profile of ne w aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicar-bazides (10a-d). The new derivatives, designed with basis on the molecular hybridization co ncept, were prepared in good yields from natural safrole ((9) under bar), i solated from sassafras oil. The anti-aggregating activity of these new derivatives (<(10a-d)under bar>) on platelet aggregation induced by ADP, collagen, arachidonic acid and U-4 6619, indicates an important antithrombotic profile for the 6-methyl-3,4-me thylenedioxyphenyl-sulfonyl-N-phenylthiosemicarbazide derivative(<(10d)unde r bar>), acting at the arachidonic acid cascade and representing a new lead -compound with antithrombotic activity.