Interrelation of abdominal type of obesity and syndrome of insulin resistance in patients with hypertension

Possible contribution of obesity (of abdominal type of fat distribution in particular) in cascade of metabolic disorders which constitute syndrome of insulin resistance was studied in a sample of Moscow male population. Blood pressure, heart rate, blood levels of total and high density lipoprotein c holesterol, triglycerides, glucose and insulin measured in fasting state an d in 2 hours after oral glucose load (75 g) were analyzed in tertiles of di stribution of body mass index and hip to waist ratio in 121 hypertensive me n aged 54+/-1,8 years. Systolic and diastolic blood pressures, plasma level s of triglycerides, insulin and glucose in fasting state and after glucose load were significantly higher (while high density lipoprotein cholesterol - significantly lower) in the third compared to first tertile of distributi on of both body mass index and hip to waist ratio. Body mass index and hip to waist ratio correlated positively with triglycerides (r=0,44 and 0,29), fasting (r=0,57 and 0,48) and post glucose load insulin (r=0,47 and 0,43), fasting (r=0,33 and 0,31) and post load (r=0,34 and 0,34) glucose, diastoli c blood pressure (r=0,32 and 0,24, respectively), and negatively with high density lipoprotein cholesterol (r=-0,32 and -0,21, respectively). Thus inc rease in degree of obesity in hypertensive men was associated with metaboli c disorders believed to be components of insulin resistance syndrome.