CYTOGENETIC CLASSIFICATION OF RENAL-CELL CANCER

Cytogenetic and molecular genetic investigations in cancer are importa nt fools to address problems of oncogenesis and tumor progression, of classification, and of diagnosis of rumors. A combination of advanced molecular genetic, cytogenetic, and (immune) histopathologic analysis will contribute significantly to the elucidation of the oncogenic step s that lead to immortalization and subsequent malignant behavior. In t his review written on the occasion of Dr. Avery Sandberg's 75th annive rsary, we will present a model for the pathogenesis of renal cell tumo rs based on a new cytomorphologic classification and our (cyto)genetic analysis of about 175 renal cell tumors, together with the accumulate d data in the literature. (C) Elsevier Science Inc., 1997.