Transient headache and impaired vision after intravenous thyrotropin-releasing hormone in a patient with pituitary macroadenoma

We report a case of transient headache and impaired vision following admini stration of intravenous thyrotropin-releasing hormone (TRH) to a woman with a non-functioning pituitary macroadenoma, visual field defect, and elevate d thyroid-stimulating hormone(TSH). The symptoms lasted for two hours and t hen resolved without known sequelae. There are a few other reported cases o f similar adverse reactions to neuroendocrine manipulation in patients with pituitary macroadenomas. This is the second reported case of such adverse reactions to TRH alone and the first in which the patient had prior elevati on of TSH.