Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway

Authors
Puglielli, MT Browning, JL Brewer, AW Schreiber, RD Shieh, WJ Altman, JD Oldstone, MBA Zaki, SR Ahmed, R
Citation
Mt. Puglielli et al., Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway, NAT MED, 5(12), 1999, pp. 1370-1374
Citations number
34
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
NATURE MEDICINE
ISSN journal
10788956 → ACNP
Volume
5
Issue
12
Year of publication
1999
Pages
1370 - 1374
Database
ISI
SICI code
1078-8956(199912)5:12<1370:ROVSSA>2.0.ZU;2-I
Abstract
At present, little is known about the pathogenesis of acute virus-induced s hock and pulmonary failure. A chief impediment in understanding the underly ing disease mechanisms and developing treatment strategies has been the lac k of a suitable animal model. This study describes a mouse model of virus-i nduced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.