A 19-year-old female on chronic peritoneal dialysis developed acute periton
itis; multiple peritoneal fluid and catheter tip cultures yielded Penicilli
um species. She promptly responded to catheter removal and intravenous amph
otericin B, followed by oral fluconazole, without further recurrences 1 yea
r later. This is the first reported case of Penicillium peritonitis in the
pediatric population. We review the microbiology and clinical spectrum of t
his disease, as well as the few previous reported cases in adults.