EFFECT OF CISAPRIDE ON THE MOTOR-ACTIVITY OF THE SPHINCTER OF ODDI INHUMANS - EVALUATION BY ENDOSCOPIC BILIARY MANOMETRY

Endoscopic manometry was performed to evaluate the effects of cisaprid e on the motor activity of the sphincter of Oddi (SO) in 13 patients w ith elevated SO pressure and 6 healthy volunteers. Cisapride was given orally to 7 patients and 3 volunteers at a dosage of 10 mg/d (group 1 ) and to 6 patients and 3 volunteers at 20 mg/d (group 2). Endoscopic manometry was performed before and 1 and 2 weeks after drug administra tion. All group 2 patients experienced a significant decrease in SO pr essure after 2 weeks, and the pattern of SO contraction waves changed from irregular to regular in half of these patients. The results sugge st that high doses of cisapride can both inhibit and stimulate SO moto r activity, thus improving motor dysfunction.