Elastic rod model of a DNA loop in the lac operon

Authors
Balaeff, A Mahadevan, L Schulten, K
Citation
A. Balaeff et al., Elastic rod model of a DNA loop in the lac operon, PHYS REV L, 83(23), 1999, pp. 4900-4903
Citations number
31
Categorie Soggetti
Physics
Journal title
PHYSICAL REVIEW LETTERS
ISSN journal
00319007 → ACNP
Volume
83
Issue
23
Year of publication
1999
Pages
4900 - 4903
Database
ISI
SICI code
0031-9007(199912)83:23<4900:ERMOAD>2.0.ZU;2-P
Abstract
We use the theory of elasticity to compute the shape of the DNA loop bridgi ng the gap in the crystal structure of the lac repressor-DNA complex. The K irchhoff system of equations with boundary conditions derived from the crys tal structure is solved using a continuation method. This approach can be a pplied effectively to find coarse-grained conformational minima of DNA loop s.