New hypolipaemic agents designed by molecular topology: Pharmacological studies of 2,6-Di-tert-butyl-4-methylpyridine and 2,6-Di-tert-butylpyridine

New compounds showing hypolipaemic activity have been designed using a comp uter-aided method based on molecular topology and QSAR analysis. Linear dis criminant analysis and connectivity functions were used to design three pot entially suitable drugs which were tested for hypolipaemic properties by th e Triton WR-1339 test in rats. The pharmacological tests carried out on the newly designed compounds demonstrated the existence of notable activity in phase I for two of them, namely 2,6-Di-tert-butyl-4-methylpyridine (C.A.S. 38222-83-2) and 2,6-Di-tert-butylpyridine (C.A.S. 585-48-8), with respect to the level of total cholesterol. Both substances decrease the lipaemia to lower levels than clofibrate, which was used as a reference drug.