H. Berard et al., Disseminated Histoplasma capsulatum infection with brain lesions 13 years after the primary infection, REV MAL RES, 16(5), 1999, pp. 829-831
A 49-year-old man with disseminated histoplasmosis (pulmonary and central n
ervous system involvement) successfully treated with ketoconazole and fluco
nazole combination is reported. Histoplasma capsulatum infection of the cen
tral nervous system is extremely rare in France partly because the organism
is not endemic. Oral treatment with newer triazoles may be useful for cent
ral nervous system histoplasmosis, but additional information is needed to
establish their effectiveness.