Condensation of diphenylphosphinylacetohydrazide with aldehydes, ketones, dicarbonyl compounds, and ethoxymethylenecyanoacetic acid ester

Condensation of diphenylphosphinylacetohydrazide with aldehydes, ketones, a nd dibenzoyl yields hydrazones. The hydrazonic fragment of these compounds in the crystalline state exists as the EE'Z " isomer, and in DMSO solution, as a mixture of rotamers stabilized by an intramolecular hydrogen bond. Re action of diphenylphosphinylacetohydrazide with glyoxal gives the correspon ding osazone, while with diethyl diacetyl-succinate a pyrrole derivative is formed. Ethoxymethylenecyanoacetic acid ester reacts with the hydrazide un der study exclusively by the ethoxymethylene group.