Embryo implantation and tumor metastasis: Common pathways of invasion and angiogenesis

Implantation of the embryo is one of the last great mysteries of reproducti ve biology. There are striking similarities present between the behavior of invasive placental cells and that of invasive cancer cells. In this review , we propose that cellular mechanisms used by the cells of the placenta dur ing implantation are reused by cancer cells to invade and spread within the body. Integrins and other cell adhesion molecules, extracellular matrix an d matrix metalloproteinases all appear to be involved and are regulated by the complex endocrine, autocrine and paracrine milieu within the uterus. An giogenesis is a common feature of both implantation and cancer spread. Endo thelial cells also use similar cellular mechanisms during angiogenesis to d igest the surrounding matrix, migrate and form Mew blood vessels. A better understanding of the mechanism of trophoblast invasion will likely lead to insights of various diseases of pregnancy such as preeclampsia. An apprecia tion of the maternal mechanisms to control this invasive behavior may likew ise lead to a better understanding of metastatic cancer cells and lead to b etter methods to control their growth and spread within host tissues.