5-Arylmethylene-2,4-imidazolidinediones and 5-arylmethylene-2-thioxo-4-imidazolidinones derivatives: stereochemistry elucidation by H-1 and C-13 NMR

Authors
Fresneau, P Morand, JM Thomasson, F Cussac, M
Citation
P. Fresneau et al., 5-Arylmethylene-2,4-imidazolidinediones and 5-arylmethylene-2-thioxo-4-imidazolidinones derivatives: stereochemistry elucidation by H-1 and C-13 NMR, SPECT ACT A, 55(14), 1999, pp. 2893-2898
Citations number
18
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
ISSN journal
13861425 → ACNP
Volume
55
Issue
14
Year of publication
1999
Pages
2893 - 2898
Database
ISI
SICI code
1386-1425(199912)55:14<2893:5A5>2.0.ZU;2-I
Abstract
Derivatives of 5-arylmethylene-2,4-imidazolidinediones and 5-arylmethylene- 2-thioxo-4-imidazolidinones were synthesized as potential aldose reductase inhibitors (ARI). The Z/E configuration was elucidated by homonuclear NOE d ifference spectra and by proton-carbon coupling constant measurement from C -13 coupled spectra using GATEDEC and SFDEC programs. (C) 1999 Elsevier Sci ence B.V. All rights reserved.