A new method for the synthesis of 5-fluorouracil prodrugs

Authors
Jolimaitre, P Andre-Barres, C Malet-Martino, M Martino, R Rico-Lattes, I
Citation
P. Jolimaitre et al., A new method for the synthesis of 5-fluorouracil prodrugs, SYNLETT, (11), 1999, pp. 1829-1831
Citations number
10
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
11
Year of publication
1999
Pages
1829 - 1831
Database
ISI
SICI code
0936-5214(199911):11<1829:ANMFTS>2.0.ZU;2-4
Abstract
Bromo-tris(dimethylamino)-phosphonium-hexafluorophosphate (BROP) is a parti cularly suitable reagent for synthesising some 5-fluorouracil prodrugs in a one step reaction. Several acids, especially retinoic acid, were bound to the N-1 of 5-fluorouracil, with yields of about 50% after purification.