Colubricidin A, a novel macrolide antibiotic from a Streptomyces sp.

Authors
Kong, FM Liu, DQ Nietsche, J Tischler, M Carter, GT
Citation
Fm. Kong et al., Colubricidin A, a novel macrolide antibiotic from a Streptomyces sp., TETRAHEDR L, 40(52), 1999, pp. 9219-9223
Citations number
3
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
52
Year of publication
1999
Pages
9219 - 9223
Database
ISI
SICI code
0040-4039(199912)40:52<9219:CAANMA>2.0.ZU;2-H
Abstract
A new 34-membered macrolide antibiotic, colubricidin A (1), was isolated fr om the fermentation broth of a new streptomyces species. Its structure was elucidated on the basis of analysis of the spectroscopic data and chemical degradation. It was identified as a glycomacrolide with an unprecedented ar omatic chromophore. Colubricidin A showed excellent activity against Gram-p ositive bacteria. (C) 1999 Elsevier Science Ltd. All rights reserved.