Liquid phase parallel synthesis of iminodiacetic acid derivatives

Liquid phase parallel synthesis has been developed to synthesize a novel se ries of iminodiacetic acid derivatives targeting the integrin receptors. Th is library was synthesized using a four-step reaction sequence. In each ste p of the sequence, the PEG-bound products were precipitated selectively and the excess reagents and the by-products were removed by simple filtration, The most notable result was that the library members were obtained in high purities (>90% pure), (C) 1999 Elsevier Science Ltd. All rights reserved.