An efficient one-pot synthesis of (+)-deoxypyridinoline

Authors
Adamczyk, M Johnson, DD Reddy, RE
Citation
M. Adamczyk et al., An efficient one-pot synthesis of (+)-deoxypyridinoline, TETRAHEDR L, 40(51), 1999, pp. 8993-8994
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
51
Year of publication
1999
Pages
8993 - 8994
Database
ISI
SICI code
0040-4039(199912)40:51<8993:AEOSO(>2.0.ZU;2-R
Abstract
An efficient one-pot synthesis of (+)-deoxypyridinoline (Dpd, 1), the cross -link of bone collagen, was achieved from tert-butyl-(S)-(-)-[(2-tert-butox ycarbonyl)amino]-6-aminohexanoate (2) and tert-butyl-(S)-(-)-6-bromo-2-[bis (tert-butoxycarbonyl)amino]-5-oxohexanoate (3) in 42% yield. (C) 1999 Elsev ier Science Ltd. All rights reserved.