Synthesis of 4-(2-diphenylphosphino-1-naphthyl)-2-phenylquinazoline; a potential P-N chelating ligand for asymmetric catalysis

We describe a multistep synthesis leading in a good yield to the title comp ound. The biaryl linkage was formed in a Pd-catalysed coupling of 2-phenyl- 4-chloroquinazoline with 2-methoxy-1-naphthylboronic acid. A further metal- catalysed reaction gave the formation of the naphthylphosphorus bond allowi ng us to obtain the required phosphonimine ligand 1 as the racemate. (C) 19 99 Elsevier Science Ltd. All rights reserved.