Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex

Authors
Kuwano, R Karube, D Ito, Y
Citation
R. Kuwano et al., Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex, TETRAHEDR L, 40(51), 1999, pp. 9045-9049
Citations number
32
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
51
Year of publication
1999
Pages
9045 - 9049
Database
ISI
SICI code
0040-4039(199912)40:51<9045:CAHO1C>2.0.ZU;2-M
Abstract
A rhodium complex coordinated with a trans-chelating chiral diphosphine (S, S)-(R,R)-PhTRAP was an effective catalyst for asymmetric hydrogenation of N -acyl-1-aza-2-cycloalkene-2-carboxylates, which gave the corresponding prot ected cyclic alpha-amino acids with 73-97% ee. (C) 1999 Elsevier Science Lt d. All rights reserved.