Absolute configuration of 2-hydroxy-2-(1-naphthyl)propionic acid as determined by the H-1 NMR anisotropy method

Authors
Ichikawa, A Hiradate, S Sugio, A Kuwahara, S Watanabe, M Harada, N
Citation
A. Ichikawa et al., Absolute configuration of 2-hydroxy-2-(1-naphthyl)propionic acid as determined by the H-1 NMR anisotropy method, TETRAHEDR-A, 10(21), 1999, pp. 4075-4078
Citations number
11
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
21
Year of publication
1999
Pages
4075 - 4078
Database
ISI
SICI code
0957-4166(19991029)10:21<4075:ACO2AA>2.0.ZU;2-D
Abstract
Enantiopure 2-hydroxy-2-(1-naphthyl)propionic acid (+)-2 was prepared by th e stereoselective Grignard reaction of 1-naphthylmagnesium bromide with (1R ,3R,4S)-menthyl pyruvate 3 or (1R,3R,4S)-8-phenylmenthyl pyruvate 4, and th e absolute configuration of acid (+)-2 was unambiguously determined to be S by the H-1 NMR anisotropy method. (C) 1999 Elsevier Science Ltd. All right s reserved.