The first asymmetric syntheses of L-homocysteine and L-homocystine

Authors
Adamczyk, M Fishpaugh, JR Thiruvazhi, M
Citation
M. Adamczyk et al., The first asymmetric syntheses of L-homocysteine and L-homocystine, TETRAHEDR-A, 10(21), 1999, pp. 4151-4156
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
21
Year of publication
1999
Pages
4151 - 4156
Database
ISI
SICI code
0957-4166(19991029)10:21<4151:TFASOL>2.0.ZU;2-V
Abstract
Asymmetric syntheses of L-homocysteine 1 and L-homocystine 2 are described. Alkylation of the carbanion derived from Schollkopf reagent 3 and ensuing hydrolyses gave S-triphenylmethyl-L-homocysteine 6, Removal of the tripheny lmethyl group gave L-homocysteine 1 and subsequent oxidation provided L-hom ocystine 2. (C) 1999 Elsevier Science Ltd. All rights reserved.