Deracemization of racemic 1,2-diol by biocatalytic stereoinversion

Authors
Goswami, A Mirfakhrae, KD Patel, RN
Citation
A. Goswami et al., Deracemization of racemic 1,2-diol by biocatalytic stereoinversion, TETRAHEDR-A, 10(21), 1999, pp. 4239-4244
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
21
Year of publication
1999
Pages
4239 - 4244
Database
ISI
SICI code
0957-4166(19991029)10:21<4239:DOR1BB>2.0.ZU;2-D
Abstract
Deracemization of racemic 1,2-diol, (RS)-1-{2',3'-dihydrobenzo[b] furan-4'- yl) -ethane-1,2-diol (1), by stereoinversion by several microorganisms belo nging to the genera Candida and Pichia provided the corresponding chiral (S )-diol, (S)-1-(2',3'-dihydrobenzo[b]furan-4'-yl)-ethane-1,2-diol (2). (S)-D iol 2 was obtained in yields of 60-70% with 90-100% enantiomeric excess. (C ) 1999 Elsevier Science Ltd. All rights reserved.