The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism Pl(A2) in patients with central retinal vein occlusion

The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa po lymorphism pl(A2) have been shown to be associated with thromboembolic dise ase. We wondered if mutations were overrepresented in patients with central retinal vein occlusion. We studied 129 consecutive patients with a history of central retinal vein occlusion. We analysed for the prothrombin gene G2 0210A mutation and the platelet glycoprotein IIIa polymorphism pl(A2) and c ompared the results to controls with no history of thrombosis. For the plat elet glycoprotein IIIa polymorphism Pl(A2), 69% were normal, 26% were heter ozygous, and 5% were homozygous. For the G20210A prothrombin mutation, 97% were normal and 3% were heterozygous. Neither the prothrombin gene G20210A mutation nor the platelet glycoprotein IIIa polymorphism pl(A2) seem to be associated with central retinal vein occlusion. (C) 1999 Elsevier Science L td. All rights reserved.