Y. Nakamura et al., High prevalence of Borna disease virus in domestic cats with neurological disorders in Japan, VET MICROB, 70(3-4), 1999, pp. 153-169
A total of 15 (T-1-T-15) domestic cats with neurological disorders in Tokyo
area were examined for association with Borna disease virus (BDV), None ha
d detectable antibodies to feline immunodeficiency virus (FIV), feline leuk
emia virus, feline infectious peritonitis virus and Toxoplasma gondii, and
only cat T-8 had detectable antibody to FIV. Serological and molecular epid
emiological studies revealed a significantly high prevalence of BDV infecti
on in these cats: antibodies against BDV p24 and/or p40 proteins in 10/15 (
66.7%) and p24 and/or p40 RNA in peripheral blood mononuclear cells in 8/15
(53,3%), Further, in situ hybridization and immunohistochemistry analyses
of the autopsied brain samples derived from one of the cats (T-15) revealed
BDV RNA predominantly in neuronal cells in restricted regions, such as olf
actory bulb and medulla of cerebrum. Thus, BDV is present in Japanese domes
tic cats with neurological disorders at a high prevalence. (C) 1999 Elsevie
r Science B,V, All rights reserved.