Synthesis and HPLC-analysis of N-(2-phenyl-cyclopropyl)-substituted chain elongated nucleoside analogues

Authors
Csuk, R Kern, A Mohr, K
Citation
R. Csuk et al., Synthesis and HPLC-analysis of N-(2-phenyl-cyclopropyl)-substituted chain elongated nucleoside analogues, Z NATURFO B, 54(11), 1999, pp. 1463-1468
Citations number
12
Categorie Soggetti
Chemistry
Journal title
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
ISSN journal
09320776 → ACNP
Volume
54
Issue
11
Year of publication
1999
Pages
1463 - 1468
Database
ISI
SICI code
0932-0776(199911)54:11<1463:SAHONC>2.0.ZU;2-1
Abstract
A novel class of nucleoside analogues containing adenine, uracil, thymine a nd 5-fluorouracil as the heterocyclic moieties have been prepared from 2-ph enylcyclopropane carboxylic acid. These compounds showed weak antitumor act ivity. The resolution of the racemates on an analytical and semipreparative scale was performed by HPLC using chiral stationary phases.