DIFFERENTIATION OF BENIGN AND MALIGNANT CERVICAL LYMPH-NODES WITH COLOR DOPPLER SONOGRAPHY

OBJECTIVE. This study proposed to evaluate the efficacy of color Doppl er sonography in detecting possible differences in blood flow patterns between malignant and benign cervical lymph nodes. SUBJECTS AND METHO DS. During a period of 12 months, the palpable cervical lymph nodes of 48 untreated patients were prospectively evaluated with color Doppler sonography and Doppler flow wave analysis. Histopathologic diagnoses were obtained by sonographically guided fine-needle aspiration biopsy and/or excisional biopsy. RESULTS. We found 16 benign lymph nodes (fou r were tuberculous lymphadenitis, four were reactive hyperplasia, and eight were unspecified) and 32 malignant lymph nodes (13 were squamous cell carcinomas, nine were adenocarcinomas, four were small-cell carc inomas, three were lymphomas, and three were miscellaneous). Color Dop pler flow patterns were seen in six (38%) of the 16 benign lymph nodes and in 29 (91%) of the 32 malignant lymph nodes. Twenty-six (81%) of the 32 malignant lymph nodes had abnormal flow patterns, with resistan ce indexes less than 0.6. However, three (19%) of the 16 benign lymph nodes also had abnormal flow patterns, and only seven (54%) of 13 squa mous cell carcinomas had abnormal flow patterns. CONCLUSION. Color Dop pler sonography has limited clinical value in differentiating malignan t from benign cervical lymph nodes and in obviating biopsy.