Trovafloxacin concentrations in airway fluids of patients with severe community-acquired pneumonia

Authors
Peleman, RA Van de Velde, V Germonpre, PR Fleurinck, C Rosseel, MT Pauwels, RA
Citation
Ra. Peleman et al., Trovafloxacin concentrations in airway fluids of patients with severe community-acquired pneumonia, ANTIM AG CH, 44(1), 2000, pp. 178-180
Citations number
13
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
1
Year of publication
2000
Pages
178 - 180
Database
ISI
SICI code
0066-4804(200001)44:1<178:TCIAFO>2.0.ZU;2-O
Abstract
The penetration of trovafloxacin (TVA), 200 mg once daily, into the airways of 17 patients with severe pneumonia was studied. The mean (standard devia tions are given in parentheses) steady-state TVA concentrations, 2 h after the last intake, were 3.1 (0.3) mg/liter in induced sputum (n = 8), 3.2 (1. 1) mg/liter in bronchial secretions (n = 9), 3.2 (0.9) mg/liter in bronchoa lveolar lavage fluid (n = 10), and 4.9 (1.4) mg/liter in epithelial lining fluid (n = 11).