Bioavailability of aciclovir after oral administration of aciclovir and its prodrug valaciclovir to patients with leukopenia after chemotherapy

The median bioavailabilities of aciclovir after administration of aciclovir and its prodrug valaciclovir were 21.5 and 70.1%, respectively, in 12 pati ents with malignant hematological diseases with leukopenia after chemothera py. The interindividual variations of the bioavailability were 48.5 and 21. 0% after administration of aciclovir and valaciclovir, respectively. Neithe r the bioavailability nor the interindividual variation of area under the c oncentration-time curve of oral aciclovir or valaciclovir differed from tha t reported in healthy volunteers.