An overview of genetic factors influencing plasma lipid levels and coronary artery disease risk

Background.--Coronary artery disease (CAD) is a major cause of morbidity an d mortality in most Western countries and its origin involves a significant genetic component. Methods.--Genetic and epidemiologic studies have been performed to identify factors that influence the CAD risk in the population. Results.--The primary loci that have been demonstrated to be associated wit h increased CAD risk owing to genetic mutations include the low-density lip oprotein receptor, apolipoprotein B-100, and lipoprotein(a), Additional imp licated loci include lipoprotein lipase, apolipoprotein CII, cholesteryl es ter transfer protein, apolipoprotein AI, and lecithin-cholesterol acyl tran sferase. Conclusions.--Numerous mutations in known genes exert a major effect on CAD risk in some patients, However, in most patients with CAD, the genetic com ponent is believed to be attributable to the aggregate effect of loci that, individually, exert only a minor influence on lipoprotein levels.