Modulation of apoptosis of human peripheral blood neutrophils by UV-C and gamma-irradiation

Authors
Vinokurov, MG Kosyakova, NI Nikolaeva, NN Pechatnikov, VA
Citation
Mg. Vinokurov et al., Modulation of apoptosis of human peripheral blood neutrophils by UV-C and gamma-irradiation, BIOFIZIKA, 44(5), 1999, pp. 929-930
Citations number
6
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOFIZIKA
ISSN journal
00063029 → ACNP
Volume
44
Issue
5
Year of publication
1999
Pages
929 - 930
Database
ISI
SICI code
0006-3029(199909/10)44:5<929:MOAOHP>2.0.ZU;2-T
Abstract
It was found that the irradiation with in vitro UVC (254 nm) in the dose ra nge of 6-600 J/m(2) accelerates the apoptosis of human peripheral blood neu trophils in a dose-dependent manner, with saturation occurring at UVC doses of 250-300 J/m2. gamma-Irradiation with a dose of 2 Gy accelerates the apo ptosis of neutrophils, whereas the irradiation with doses of 10 and 20 Gy s uppresses it (by 9 h of cultivation). Lipopolysaccharide (1 mu g/ml) supres ses the UVC-induced apoptosis of neutrophils.