Lim and Wolfe (1997, Biometrics 53, 410-418) proposed rank-based multiple t
est procedures for identifying the dose levels that are more effective than
the zero-dose control in randomized complete block designs when it can be
assumed that the efficacy of the increasing dose levels is monotonically in
creasing up to a point, followed by a monotonic decrease. Modifications of
the Lim-Wolfe tests are suggested that provide more practical and powerful
alternatives. Two numerical examples are illustrated and the results of a M
onte Carlo power study are presented.