Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-ones (TIBO) analogues

4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-ones ( TIBO), 1, have been shown to significantly inhibit HIV-1 replication, as re ported in detail in our prior publications. Since our earlier reports, we h ave modified the TIBO structures 1 by removing the 5-membered ring of 1, ge nerating 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-ones (TBO), 4, a bicycli c series of compounds. Although compounds 4 possess modest activity when co mpared to TIBO analogues 1, they clearly demonstrated significant anti-HIV- 1 activity. (C) 1999 Elsevier Science Ltd. All rights reserved.