scyllo-Inositol is the all equatorial stereoisomer of myo-inositol. All pos
sible 12 regioisomers of scyllo-inositol phosphate were synthesized for the
first time via a scyllo-inositol benzoate intermediate, which was derived
from a myo-inositol derivative. The stereoinversion of myo-inositol into sc
yllo-inositol was accomplished by Mitsunobu reaction of the vicinal cis-dio
l. The requisite intermediates, scyllo-inositol benzoates were obtained by
benzoyl migration or random benzoylation, and phosphorylated to give scyllo
-IPn. (C) 1999 Elsevier Science Ltd. All rights reserved.