In search of new chemical entities with spermicidal and anti-HIV activities

Authors
Srivastava, S Bajpai, LK Batra, S Bhaduri, AP Maikhuri, JP Gupta, G Dhar, JD
Citation
S. Srivastava et al., In search of new chemical entities with spermicidal and anti-HIV activities, BIO MED CH, 7(11), 1999, pp. 2607-2613
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
7
Issue
11
Year of publication
1999
Pages
2607 - 2613
Database
ISI
SICI code
0968-0896(199911)7:11<2607:ISONCE>2.0.ZU;2-I
Abstract
Several compounds belonging to 2-isoxazolines (4,5a-c), isoxazoles (3,6a-c) and 1-amino-1-cycloalkyl-2-substituted phenyl ethanes (16-18,a-e) have bee n synthesised and found to possess spermicidal activity. Out of these a cou ple of compounds (5a and 6a) exhibit anti-HIV activity. (C) 1999 Elsevier S cience Ltd. All rights reserved.