Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonellaaff. mirabilis

Authors
Fusetani, N Fujita, M Nakao, Y Matsunaga, S van Soest, RWM
Citation
N. Fusetani et al., Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonellaaff. mirabilis, BIOORG MED, 9(24), 1999, pp. 3397-3402
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
24
Year of publication
1999
Pages
3397 - 3402
Database
ISI
SICI code
0960-894X(199912)9:24<3397:TAANCB>2.0.ZU;2-2
Abstract
A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the ma rine sponge Theonella aff. mirabilis. Its structure was determined by spect roscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC 50 value of 29.0 ng / mL. (C) 1999 Elsevier Science Ltd. All rights reserve d.