Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages

Authors
Honda, T Rounds, BV Bore, L Favaloro, FG Gribble, GW Suh, N Wang, YP Sporn, MB
Citation
T. Honda et al., Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages, BIOORG MED, 9(24), 1999, pp. 3429-3434
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
24
Year of publication
1999
Pages
3429 - 3434
Database
ISI
SICI code
0960-894X(199912)9:24<3429:NSOTAS>2.0.ZU;2-2
Abstract
Novel oleanane triterpenoids with modified rings A and C were designed and synthesized. Among them, methyl 2-carboxy-3,12-dioxooleana-1,9-dien-28-oate showed similar high inhibitory activity (IC50 = 0.8 nM) to 2-cyano-3,12-di oxooleana-1,9-dien-28-oic acid (CDDO), which we have synthesized previously , against production of nitric oxide induced by interferon-gamma in mouse m acrophages. (C) 1999 Elsevier Science Ltd. All rights reserved.