Citation
J. Cossy et al., A short synthesis of troglitazone: An antidiabetic drug for treating insulin resistance, BIOORG MED, 9(24), 1999, pp. 3439-3440
Citations number
4
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X
→ ACNP
Volume
9
Issue
24
Year of publication
1999
Pages
3439 - 3440
Database
ISI
SICI code
0960-894X(199912)9:24<3439:ASSOTA>2.0.ZU;2-L
Abstract
Troglitazone was obtained in 5 steps from 4-bromo-1,1-dimethoxy-3-methylbut
-2-ene with an overall yield of 7.5%. The formation of the chromane ring wa
s achieved by condensing an unsaturated acetal with trimethylhydroquinone i
n the presence of bis(trifluoromethylsulfonyl)imide. (C) 1999 Elsevier Scie
nce Ltd. All rights reserved.