Novel synthetic analogs of the Pseudomonas autoinducer

Authors
Kline, T Bowman, J Iglewski, BH de Kievit, T Kakai, Y Passador, L
Citation
T. Kline et al., Novel synthetic analogs of the Pseudomonas autoinducer, BIOORG MED, 9(24), 1999, pp. 3447-3452
Citations number
29
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
24
Year of publication
1999
Pages
3447 - 3452
Database
ISI
SICI code
0960-894X(199912)9:24<3447:NSAOTP>2.0.ZU;2-H
Abstract
Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-I and PAI-2, that activate the respective tr anscription factors LasR and RhlR. With the goal of developing novel therap eutic agents, we synthesized constrained analogs of PAI-I and evaluated the m in P. aeruginosa, Two of the novel analogs bound to LasR and showed agoni st activity in LasR stimulation of a lasI-lacZ reporter construct. (C) 1999 Elsevier Science Ltd. All rights reserved.