Al. Satz et Tc. Bruice, Synthesis of a fluorescent microgonotropen (FMGT-1) and its interactions with the dodecamer d(CCGGAATTCCGG), BIOORG MED, 9(23), 1999, pp. 3261-3266
A new type of microgonotropen that fluoresces upon binding to dsDNA has bee
n synthesized. FMGT-1, an analogue of the minor groove binder Hoechst 33258
, is functionalized with a polyamine chain capable of interacting with the
phosphate backbone of DNA. Binding studies indicate that FMGT-1 binds more
tightly to dsDNA than the parent compound Hoechst 33258. (C) 1999 Elsevier
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