Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs

Authors
Ishida, J Wang, HK Bastow, KF Hu, CQ Lee, KH
Citation
J. Ishida et al., Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs, BIOORG MED, 9(23), 1999, pp. 3319-3324
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
23
Year of publication
1999
Pages
3319 - 3324
Database
ISI
SICI code
0960-894X(199912)9:23<3319:AA2COH>2.0.ZU;2-K
Abstract
Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a hu man tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. alpha-(4-Nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3-1.2 mu g/mL against 1A9, KB, Sa OS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells). (C) 1999 Published by Else vier Science Ltd. All rights reserved.