N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter

Authors
Prakash, KRC Tamiz, AP Araldi, GL Zhang, M Johnson, KM Kozikowski, AP
Citation
Krc. Prakash et al., N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter, BIOORG MED, 9(23), 1999, pp. 3325-3328
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
23
Year of publication
1999
Pages
3325 - 3328
Database
ISI
SICI code
0960-894X(199912)9:23<3325:NTAOBC>2.0.ZU;2-9
Abstract
A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inh ibit high affinity uptake of dopamine (DA) and serotonin (5-HT) into striat al nerve endings (synaptosomes). Some of these compounds exhibit high affin ity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50. (C) 1999 Elsevier Science Ltd. All rights reserved.