4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: Potent and selective inhibitors of ZAP 70.

Authors
Moffat, D Davis, P Hutchings, M Davis, J Berg, D Batchelor, M Johnson, J O'Connell, J Martin, R Crabbe, T Delgado, J Perry, M
Citation
D. Moffat et al., 4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: Potent and selective inhibitors of ZAP 70., BIOORG MED, 9(23), 1999, pp. 3351-3356
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
23
Year of publication
1999
Pages
3351 - 3356
Database
ISI
SICI code
0960-894X(199912)9:23<3351:4PAS>2.0.ZU;2-X
Abstract
Activation of the tyrosine kinase ZAP 70 has been shown to be crucial to th e transduction of the T-cell receptor signalling pathway, which leads ultim ately to proliferation, cytokine gene expression and T-cell effector functi ons. A series of 2-phenylaminopyrimidines have been identified as potent an d selective inhibitors of ZAP 70(1) (C) 1999 Elsevier Science Ltd. All righ ts reserved.