4-hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidines: Selective h5-HT1D agonists for the treatment of migraine.

Authors
Bourrain, S Neduvelil, JG Beer, MS Stanton, JA Showell, GA MacLeod, AM
Citation
S. Bourrain et al., 4-hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidines: Selective h5-HT1D agonists for the treatment of migraine., BIOORG MED, 9(23), 1999, pp. 3369-3374
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
23
Year of publication
1999
Pages
3369 - 3374
Database
ISI
SICI code
0960-894X(199912)9:23<3369:4S>2.0.ZU;2-X
Abstract
A series of 4-hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl] pi peridines was investigated as potential selective h5-HT1D agonists for the treatment of migraine. The 4-[(N-benzyl-N-methyl)amino]methyl analog 12a wa s found to be a full agonist at the h5-HT1D receptor with good binding sele ctivity over the h5-HT1B receptor. (C) 1999 Elsevier Science Ltd. Ali right s reserved.